Schedule: Monday - Saturday - 8:00 - 18:00, Sunday - 8:00 - 14:00
333 7892 416

cialis (tadalafil)

Cialis is the medicine that works miracles

cialis (tadalafil)

Tablets Cialis for erectile dysfunction treatment:

Cialis is the medicine that works miracles. Its principle of work is the same of Viagra – the drug inhibits PDE5 that is contained in the issues of a penis. But it is better than other analogues known earlier by its force and the effect retention. Particularly it is safer for elderly men than other drugs. Tadalafil is the main component of the drug that does not evoke erection. It aims at the retention of the penis erected. It may help to overcome the physiological problem of the erection dysfunction. Its main advantage is almost full absence of side effects.

Information for physicians:

The pills contain tadalafil, which is the main active ingredient that selectively delays the activity of cyclic guanosine monophosphate (cGMP). CGMP is the nucleotide of RNA. As a rule in the man’s organism during the sexual activity the local emission of NO (nitric oxide) is produced, the activity of specific phosphodiesterase type 5 (PDE5) that takes part in the signal reactions decreases, but in the corpus cavernosum the number of cGMP increases. Tadalafil helps to correct this. Drug intake has the reverse effect and namely the penile blood inflow and the relaxation of smooth muscle. But it does not cause, i.e. erection, but only facilitates its occurrence and keep the potency during the sexual stimulation. It is important to know that the medicine does not influence significantly to other types of phosphodiesterase (PDE) so the negative impact on other organs as liver, heart and cardiovascular system and skeletal muscles come to minimum. Moreover tadalafil does not influence on the sperm quality. Pills do not cause an increase or decrease of the testosterone level that is synthesized with the help of the stimulating hormones produced by the hypophysis. PDE5 is an enzyme that is always present in the smooth muscle of the corpus cavernosum and other organs. The drug is developed in such a way that the impact on this enzyme exceeds in 10 thousand times the impact on the other PDE - it blocks the phosphodiesterase-5 in order to keep a full erection. If you lead an active sex life you will be able to achieve the desired effect by Cialis intake. The drug begins to act within 15 minutes and remains active for 36 hours following intake. The main component of the pills Tadalafil is well absorbed by the cells of the organism after its intake. The peak period concentration in plasma occurs approximately after two hours after oral administration. The food intake does not influence the absorbent properties of the drug. Practically all Tadalafil (94%) is entirely bound with plasma proteins. The drug is excreted through kidney and intestine within 18 hours in the process of metabolism.

Prescription of Cialis:

At erectile dysfunction.

How to administrate:

The medication is designed for oral administration. It is released in the form of tablet in the shell. It is taken whole with water or tea, anytime of day with or without food. Usually the physician develops a scheme of the Cialis intake. The scheme depends on two factors: age and sexual activity. As a rule, 1 tablet is administered 20 minutes before sex, but you can drink it earlier, taking into consideration the 36-hour effect of the drug. Only one tablet can be administrated per day.

Side effects:

In rare cases the medicine may provoke dyspepsia (hampered digestion) and headache. Also In single instances were registered: back pain, swelling of the face, and sinuses, pain in the muscles, the eyes, swelling and redness of the conjunctiva, dizziness, angioedema. Also there is data that the prolonged use, overdosage or individual intolerance may be the cause of priapism of long erection. If you have more than 4 hours erection you should immediately call your physician. This may have unfavorable consequences up to absolute erectile dysfunction for a long period of time or the injury of the penis.

Are there the contradictions for the medicine use?

Strictly is contradicted to:

  • women
  • children up to 18 years old
  • in the case of the registered allergic reaction to Tadalafil
  • to patients who are using organic nitrates (medication containing NO, for example, nitroglycerine)

Is not recommended:

  • people with diseases of cardiovascular system
  • patients who have suffered myocardial infarction, apoplectic shock
  • if the patient has in the anamnesis heart failure of II grade, stenocardia, arrhythmia, hypertension, hypotension

With caution is prescribed at the following diseases:

  • risk of priapism
  • leukemia, Peyronie's disease, multiple myeloma, cavernous fibrosis, angular curvature of the penis, serbophobia anemia
  • to patients with liver and kidney dysfunction
  • to patients who receive alpha blockers, in particular, urological drugs

The interaction of Tadalafil and other medication:

It is contradicted to use Cialis with organic nitrates. With caution - erythromycin, saquinavir, ketoconazole, ritonavir. The effectiveness of the drug may decrease when used with inducers CYP3 A4. Cialis may increase the action of the medications for pressure drop. Antacids impair the absorption performance of Cialis.

What happens at overdose?

If the reactions described in the side effects are presented, the symptomatic treatment is prescribed, the medication use is cancelled.

Storage conditions:

The medication is kept two years from production date at the temperature 15-30 degrees C.